Water → N-(2-Benzoylphenyl)-2-bromoacetamide

HRID 1456633ノート

反応式

HRID 1456633 の反応式
[Br:1][CH2:2][C:3](Br)=[O:4].[NH2:6][C:7]1[CH:20]=[CH:19][CH:18]=[CH:17][C:8]=1[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:10].O>ClCCl>[Br:1][CH2:2][C:3]([NH:6][C:7]1[CH:20]=[CH:19][CH:18]=[CH:17][C:8]=1[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:10])=[O:4]

参加物

5

反応物 3

HCID 962WaterHCID 61147Bromoacetyl bromideHCID 760802-Aminobenzophenone

生成物 1

HCID 84439N-(2-Benzoylphenyl)-2-bromoacetamide収率 97.4%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

反応条件

温度
-5 °C

実験手順

A solution of bromoacetyl bromide (100 mL, 1.15 mol, Aldrich) dissolved in dichloromethane (300 mL) was added over 30 min to a solution of 2-aminobenzophenone (197 g, 1.0 mol, Fluka) dissolved in dichloromethane (1.3 L) and water (100) mL) cooled to -10° C. under vigorous mechanical stirring. The resulting mixture was stirred for an additional 1 h at --5° C. and then was allowed to warm to ambient temperature. The layers were separated, and the organic extract was washed with dilute sodium bicarbonate, then was dried over sodium sulfate. Evaporation afforded 309.8 g (95%) of 2-bromoacetamidobenzophenone as off-white crystals.

後処理

  1. temperatureto warm to ambient temperature
  2. customThe layers were separated
  3. extractionthe organic extract
  4. washwas washed with dilute sodium bicarbonate
  5. dry with materialwas dried over sodium sulfate
  6. customEvaporation

出典と根拠

ORDレコード
ord-e71c6b111918467d8dba1546a08d3400
出典データセット
uspto-grants-1998_12
特許番号
US05843941

反応ノート

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