((2(S)-Benzoylamino-3-methylbutyryl)-(3-nitrobenzyl)amino)acetic Acid Ethyl Ester → ((2(S)-Benzoylamino-3-methylbutyryl)-(3-aminobenzyl)amino)acetic Acid Ethyl Ester
反応式
[CH2:1]([O:3][C:4](=[O:32])[CH2:5][N:6]([C:17](=[O:31])[C@@H:18]([NH:22][C:23](=[O:30])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[CH:19]([CH3:21])[CH3:20])[CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([N+:14]([O-])=O)[CH:9]=1)[CH3:2]>CO.[Pd]>[CH2:1]([O:3][C:4](=[O:32])[CH2:5][N:6]([C:17](=[O:31])[C@@H:18]([NH:22][C:23](=[O:30])[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1)[CH:19]([CH3:21])[CH3:20])[CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([NH2:14])[CH:9]=1)[CH3:2]参加物
4
実験手順
A mixture of compound 734 (1.5 g, 3.4 mmol) and 10% Pd/C (150 mg) in MeOH (35 mL) was placed under H2 (1 atm) and stirred until the reduction was complete. The H2 was replaced with nitrogen and the reaction filtered. The filtrate was concentrated to provide 1.38 g of compound 735. ##STR114##