Triethylamine → HCID 22104000、化合物

HRID 1457227ノート

反応式

HRID 1457227 の反応式
C1(N=C=NC2CCCCC2)CCCCC1.[C:16]([NH:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][C:30]([OH:32])=O)(=[O:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.Cl.[CH2:34]([O:36][C:37](=[O:40])[CH2:38][NH2:39])[CH3:35].C(N(CC)CC)C.ON1C2C=CC=CC=2N=N1>O1CCCC1>[CH2:34]([O:36][C:37](=[O:40])[CH2:38][NH:39][C:30](=[O:32])[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][NH:24][C:16](=[O:23])[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1)[CH3:35]

参加物

7

反応物 5

HCID 8471TriethylamineHCID 10868DicyclohexylcarbodiimideHCID 703886-Benzamidohexanoic acidHCID 757711-HydroxybenzotriazoleHCID 2723640Glycine ethyl ester, hydrochloride

生成物 1

HCID 22104000HCID 22104000、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

反応条件

温度
0 °C

実験手順

A solution of dicyclohexylcarbodiimide (112 mmoles) in anhydrous tetrahydrofuran (44 ml) was gradually added to a suspension of N-benzoyl-6-aminohexanoic acid (93.5 mmoles), prepared as described in example 1, glycine ethyl ester hydrochloride (112 mmoles), triethylamine (112 mmoles) and anhydrous 1-hydroxybenzotriazole (112 mmoles) in tetrahydrofuran (330 ml), kept under stirring at 0° C. The reaction mixture was brought at room temperature and kept under stirring for 16 hours.

後処理

  1. customprepared
  2. customwas brought at room temperature
  3. stirringunder stirring for 16 hours

出典と根拠

ORDレコード
ord-72d1a84a6c4e45029ce97a96436ac908
出典データセット
uspto-grants-1998_12
特許番号
US05847092

反応ノート

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