Water → 2-Hydroxy-3-phenylaminocarbonyl-6-hydroxycarbonylnaphthalene

HRID 1457439ノート

反応式

HRID 1457439 の反応式
[C:1]1([NH:7][C:8]([C:10]2[C:11](C([O-])=O)=[CH:12][C:13]3[C:18]([CH:19]=2)=[CH:17][C:16]([C:20]([O:22]C)=[O:21])=[CH:15][CH:14]=3)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Na+].[OH2:28].[OH-].[Na+]>CO>[OH:28][C:11]1[C:10]([C:8]([NH:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[O:9])=[CH:19][C:18]2[C:13](=[CH:14][CH:15]=[C:16]([C:20]([OH:22])=[O:21])[CH:17]=2)[CH:12]=1

参加物

5

反応物 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 23666583HCID 23666583、化合物

生成物 1

HCID 109797242-Hydroxy-3-phenylaminocarbonyl-6-hydroxycarbonylnaphthalene収率 85%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Sodium 3-phenylaminocarbonyl-6-methoxycarbonyl-2-naphthoate (0.081 g) obtained in Example 29 was suspended in methanol (8.10 g) and deionized water (8.13 g) and 1N-sodium hydroxide (4.0 g) was added dropwise under ice-cooling, followed by stirring overnight. The reaction solution was freeze-dried and the resultant solid was dissolved in water. The solution was acidified with diluted hydrochloric acid and the deposited crystal was filtered. The crystal was dried under reduced pressure to obtain 0.057 g of 2-hydroxy-3-phenylaminocarbonyl-6-hydroxycarbonylnaphthalene.

後処理

  1. temperaturecooling
  2. customThe reaction solution was freeze-dried
  3. dissolutionthe resultant solid was dissolved in water
  4. filtrationthe deposited crystal was filtered
  5. customThe crystal was dried under reduced pressure

出典と根拠

ORDレコード
ord-b3e1a3ed466142e396de7be6e94de269
出典データセット
uspto-grants-1998_12
特許番号
US05847233

反応ノート

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