Methylamine → 1-(6-Fluoropyridin-3-yl)-N-methylmethanamine

HRID 1457883ノート

反応式

HRID 1457883 の反応式
[CH3:1][NH2:2].[F:3][C:4]1[N:9]=[CH:8][C:7]([CH2:10]Br)=[CH:6][CH:5]=1>CC#N>[F:3][C:4]1[N:9]=[CH:8][C:7]([CH2:10][NH:2][CH3:1])=[CH:6][CH:5]=1

参加物

4

反応物 2

HCID 6329MethylamineHCID 220506385-(Bromomethyl)-2-fluoropyridine

生成物 1

HCID 224503141-(6-Fluoropyridin-3-yl)-N-methylmethanamine収率 61%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

To a mixture of 2.5 g of 40% aqueous methylamine solution and 30 ml of CH3CN was added dropwise 3.0 g of crude (6-fluoro-3-pyridyl)methyl bromide with constant stirring. The mixture was allowed to stand at room temperature overnight and concentrated under reduced pressure. The residue was extracted with AcOEt and the extract was dried over MgSO4 and concentrated. The procedure gave 1.35 g of the title compound as a crude orange-colored oil.

後処理

  1. concentrationconcentrated under reduced pressure
  2. extractionThe residue was extracted with AcOEt
  3. dry with materialthe extract was dried over MgSO4
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-d10a02e611e742cda4677f6d59e5e0df
出典データセット
uspto-grants-1998_12
特許番号
US05849768

反応ノート

読み込み中…