Methyl iodide → HCID 22101417、化合物
反応式
[Br:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([S:12]([CH3:15])(=[O:14])=[O:13])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].CI.[C:18](=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[Br:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([S:12]([CH3:15])(=[O:14])=[O:13])=[CH:7][C:3]=1[C:4]([O:6][CH3:18])=[O:5]参加物
5
実験手順
5.8 g of 2-bromo-4-fluoro-5-methylsulphonylbenzoic acid are stirred, at room temperature for 12 h, in 20 ml of DMF together with 3.7 ml of methyl iodide and 8.3 g of potassium carbonate. The reaction mixture is then concentrated and 50 ml of water are added to it. The resulting precipitate is filtered off with suction and dried. Methyl 2-bromo-4-fluoro-5-methylsulphonylbenzoate is obtained, m.p. 126°.
後処理
- concentrationThe reaction mixture is then concentrated
- addition50 ml of water are added to it
- filtrationThe resulting precipitate is filtered off with suction
- customdried
出典と根拠
- ORDレコード
- ord-e7e81265df5449dca25d05449d7eb82e
- 出典データセット
- uspto-grants-1998_12
- 特許番号
- US05849796
反応ノート
読み込み中…