Sodium Hydroxide → 1-(1-Benzyloxycarbonyl-3-azetidinyl)cyclopropanecarboxylic acid

HRID 1458000ノート

反応式

HRID 1458000 の反応式
[CH2:1]([O:8][C:9]([N:11]1[CH2:14][CH:13]([C:15]2([C:18]([O:20]CC)=[O:19])[CH2:17][CH2:16]2)[CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>C(O)C>[CH2:1]([O:8][C:9]([N:11]1[CH2:12][CH:13]([C:15]2([C:18]([OH:20])=[O:19])[CH2:17][CH2:16]2)[CH2:14]1)=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 54249419Ethyl 1-(1-benzyloxycarbonyl-3-azetidinyl)cyclopropanecarboxylate

生成物 1

HCID 542820731-(1-Benzyloxycarbonyl-3-azetidinyl)cyclopropanecarboxylic acid収率 97%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To 2.68 g (8.83 mmol) of ethyl 1-(1-benzyloxycarbonyl-3-azetidinyl)cyclopropanecarboxylate dissolved in 27 ml of ethanol was added 27 ml of 1N sodium hydroxide aqueous solution, followed by overnight stirring at room temperature. After evaporation of the solvent, the resulting residue was mixed with 10% citric acid aqueous solution, extracted with chloroform (50 ml×3) and then dried over anhydrous sodium sulfate. By evaporating the solvent, 2.35 g (97%) of the title compound was obtained.

後処理

  1. customAfter evaporation of the solvent
  2. additionthe resulting residue was mixed with 10% citric acid aqueous solution
  3. extractionextracted with chloroform (50 ml×3)
  4. dry with materialdried over anhydrous sodium sulfate
  5. customBy evaporating the solvent

出典と根拠

ORDレコード
ord-3b9e912f4f134c10a7cfa9425467bc23
出典データセット
uspto-grants-1998_12
特許番号
US05849757

反応ノート

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