Dimethyl Sulfide → Neryl chloride
反応式
[Cl:1]N1C(=O)CCC1=O.CSC.O[CH2:13]/[CH:14]=[C:15](/[CH3:22])\[CH2:16][CH2:17][CH:18]=[C:19]([CH3:21])[CH3:20]>ClCCl>[CH2:13]([Cl:1])/[CH:14]=[C:15](\[CH2:16][CH2:17][CH:18]=[C:19]([CH3:21])[CH3:20])/[CH3:22]参加物
5
反応条件
- 温度
- 0 °C
実験手順
To a solution of N-chlorosuccinimide (10.0 g) and dimethylsulfide (6.56 ml) in dichloromethane (200 ml) was added nerol (7.71 g) while being cooled with ice. The mixture was stirred at 0° C. for 4 hours. The reaction solution was washed with brine and dried over sodium sulfate anhydride. Then, the solvent was evaporated, thereby yielding a raw product of neryl chloride. In a manner similar to Reference Example 1, this raw product was reacted with methyl 4- hydroxybenzoate (7.61 g) and then hydrolyzed to yield 7.47 g (55%) of 4- neryloxybenzoic acid.
後処理
- temperaturewhile being cooled with ice
- washThe reaction solution was washed with brine
- dry with materialdried over sodium sulfate anhydride
- customThen, the solvent was evaporated
出典と根拠
- ORDレコード
- ord-5ee97ca79b524419b25d3fb838c02837
- 出典データセット
- uspto-grants-1998_12
- 特許番号
- US05849930
反応ノート
読み込み中…