Tetrabutylammonium Fluoride → 4-(3-Methylisoxazol-5-yl)butan-1-ol

HRID 1458352ノート

反応式

HRID 1458352 の反応式
[Si]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]1[O:17][N:16]=[C:15]([CH3:18])[CH:14]=1)(C(C)(C)C)(C)C.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>O1CCCC1>[CH3:18][C:15]1[CH:14]=[C:13]([CH2:12][CH2:11][CH2:10][CH2:9][OH:8])[O:17][N:16]=1

参加物

4

反応物 2

HCID 2724141Tetrabutylammonium FluorideHCID 221009045-[4-(Tert-butyldirnethylsilanyloxy)butyl]-3-methylisoxazole

生成物 1

HCID 221009164-(3-Methylisoxazol-5-yl)butan-1-ol収率 72.9%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 5-[4-(tert-butyldirnethylsilanyloxy)butyl]-3-methylisoxazole (350 mg in 5 mL dry tetrahydrofuran) at 0° C. was added 1.62 mL of a 1M solution of tetrabutylammonium fluoride in tetrahydrofuran and the mixture stirred while warming to room temperature. After 16 hours, the mixture was concentrated in vacuo and the residue purified by flash chromatography on silica gel (ethyl acetate:hexane, 1:3, then 1:1) to give the title compound (147 mg).

後処理

  1. concentrationthe mixture was concentrated in vacuo
  2. customthe residue purified by flash chromatography on silica gel (ethyl acetate

出典と根拠

ORDレコード
ord-a5ce27bcc5534cc5b3eedb0f54a1e2cf
出典データセット
uspto-grants-1998_12
特許番号
US05849764

反応ノート

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