反応式
Cl[C:2]1[C:7]([F:8])=[C:6]([Cl:9])[N:5]=[CH:4][N:3]=1.[CH3:10][C@H:11]1[CH2:16][CH2:15][CH2:14][C@@H:13]([CH3:17])[NH:12]1>>[Cl:9][C:6]1[C:7]([F:8])=[C:2]([N:12]2[C@H:13]([CH3:17])[CH2:14][CH2:15][CH2:16][C@@H:11]2[CH3:10])[N:3]=[CH:4][N:5]=1参加物
3
反応条件
- 温度
- 70 °C
実験手順
0.25 g of 4,6-dichloro-5-fluoropyrimidine and 0.34 g of cis-2,6-dimethylpiperidine were mixed and stirred for 11 hours at 70° C. The reaction mixture was subjected to silica gel column chromatography to obtain 0.21 g of 4-chloro-6-(cis-2,6-dimethylpiperidino)-5-fluoropyrimidine.
出典と根拠
- ORDレコード
- ord-0817df69e5fb453f85648bdb00310dde
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07732448B2
関連ノート
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