(3-PHENYL-ALLYL)-PHOSPHONIC ACID DIETHYL ESTER → HCID 10538986、化合物
反応式
[C:1]1(/[CH:7]=[CH:8]/[CH2:9][P:10]([O:15][CH2:16][CH3:17])(=[O:14])[O:11][CH2:12][CH3:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>C(O)C.[Pd]>[C:1]1([CH2:7][CH2:8][CH2:9][P:10](=[O:14])([O:11][CH2:12][CH3:13])[O:15][CH2:16][CH3:17])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1参加物
4
実験手順
A solution of compound 5e (30 mg) in ethanol (5 mL) was hydrogenated over 10% Pd/C (5 mg) at atmospheric pressure. The mixture was vigorously stirred at r.t for 3 h, whereupon the catalyst was removed by filtration and the filtrate concentrated under reduced pressure to afford 7a as a colorless oil (30 mg, 99% yield). 1H NMR (CDCl3) δ1.30 (t, J=7.1 Hz, 6 H), 1.69-1.77 (m, 2 H), 1.91-1.94 (m, 2 H), 2.69 (t, J=7.5 Hz, 2 H), 4.04-4.10 (m, 4 H), 7.16-7.30 (m, 5 H).
後処理
- customwas removed by filtration
- concentrationthe filtrate concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-58a07b6bfbd64df0957580278dc1ac9b
- 出典データセット
- uspto-grants-1998_12
- 特許番号
- US05852198
反応ノート
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