Hydrochloric Acid → (2R,3R,4R)-3,4-dihydroxy-2-hydroxymethyl-1-methylpyrrolidine, hydrochloride
反応式
C([O:8][C@H:9]1[C@H:13]([O:14]CC2C=CC=CC=2)[CH2:12][N:11]([CH3:22])[C@@H:10]1[CH2:23][O:24]CC1C=CC=CC=1)C1C=CC=CC=1.[ClH:32]>[Pd].C(O)C>[ClH:32].[OH:8][C@H:9]1[C@H:13]([OH:14])[CH2:12][N:11]([CH3:22])[C@@H:10]1[CH2:23][OH:24]参加物
5
実験手順
A mixture of (2R,3R,4R)-3,4-dibenzyloxy-2-benzyloxymethyl-1-methylpyrrolidine (Compound 3) (38 mg, 0.067 mmol), 10% Pd/C (30 mg), 4 N HCl (0.1ml) and 99.9% ethanol (5 ml) was reduced in a Parr apparatus at 40 psi for 20 hours. The mixture was filtered and evaporated in vacuo to give (2R,3R,4R)-3,4-dihydroxy-2-hydroxymethyl-1-methylpyrrolidine, hydrochloride (15 mg, yield 88%) as a yellow oil.
後処理
- filtrationThe mixture was filtered
- customevaporated in vacuo
出典と根拠
- ORDレコード
- ord-1ef4b34650bb4652acb1c87612ab26b9
- 出典データセット
- uspto-grants-1998_12
- 特許番号
- US05854272
反応ノート
読み込み中…