2-Chlorophenol → 4-(2-Chlorophenoxy)butanoic acid

HRID 14598

反応式

HRID 14598 の反応式
[Na].[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[OH:9].[O:10]1[CH2:14][CH2:13][CH2:12][C:11]1=[O:15]>C(O)C>[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[O:9][CH2:14][CH2:13][CH2:12][C:11]([OH:15])=[O:10]

参加物

5

反応物 3

HCID 72452-ChlorophenolHCID 7302Gamma-ButyrolactoneHCID 5360545Sodium

生成物 1

HCID 30143434-(2-Chlorophenoxy)butanoic acid収率 80.4%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

反応条件

温度
150 °C

実験手順

To a solution of sodium (405 mg, 1.08 mmol) in ethanol (11.1 mL) was added 2-chlorophenol and the reaction mixture was stirred for 5 minutes before adding dihydro-furan-2-one (1.4 g, 16.1 mmol). The reaction mixture was stirred for 5 hours at 100° C. after which time the ethanol was slowly evaporated by continuous heating to 150° C. for another 12 hours. After such time the residue was dissolved in water (7 mL) and aqueous hydrochloric acid (1N) was added until precipitation occurred. The precipitate was isolated by filtration, washed with water and dried in vacuo to yield the title compound as yellow solid (2.79 g, 80.4%).

後処理

  1. customwas slowly evaporated
  2. dissolutionAfter such time the residue was dissolved in water (7 mL)
  3. additionaqueous hydrochloric acid (1N) was added until precipitation
  4. customThe precipitate was isolated by filtration
  5. washwashed with water
  6. customdried in vacuo

出典と根拠

ORDレコード
ord-cc003b4b1f0546ffbf7061ce23672dbe
出典データセット
uspto-grants-2010_06
特許番号
US07732452B2

関連ノート

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