Sodium Chloride → Propanamide, 2,2′-azobis[N-[2-[(2-hydroxyethyl)amino]ethyl]-2-methyl-

HRID 1459898ノート

反応式

HRID 1459898 の反応式
[N:1]([C:10]([CH3:16])([CH3:15])[C:11]([O:13]C)=O)=[N:2][C:3]([CH3:9])([CH3:8])[C:4]([O:6]C)=O.[NH2:17][CH2:18][CH2:19][NH:20][CH2:21][CH2:22][OH:23].[Cl-].[Na+]>CO>[N:2]([C:3]([CH3:8])([CH3:9])[C:4]([NH:17][CH2:18][CH2:19][NH:20][CH2:21][CH2:22][OH:23])=[O:6])=[N:1][C:10]([CH3:16])([CH3:15])[C:11]([NH:17][CH2:18][CH2:19][NH:20][CH2:21][CH2:22][OH:23])=[O:13]

参加物

5

反応物 3

HCID 5234Sodium ChlorideHCID 8112N-(2-Hydroxyethyl)ethylenediamineHCID 757631,1'-Dimethyl 2,2'-(1,2-diazenediyl)bis(2-methylpropanoate)

生成物 1

HCID 54254381Propanamide, 2,2′-azobis[N-[2-[(2-hydroxyethyl)amino]ethyl]-2-methyl-収率 80%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a constantly stirred mixture comprising 23.0 g of V-601, 22.9 g of 2-(2-aminoethylamino)ethanol and 5 ml of methanol, 4.7 g of 28% CH3 ONa was added dropwise. The reaction was carried out with stirring at room temperature for 8 hours. After standing overnight, the reaction mixture was mixed with 50 ml of saturated sodium chloride solution, and extracted with 100 ml of dichloromethane. The organic layer was dried over anhydrous magnesium sulfate and solvent was distilled off, and there was obtained 29.8 g (yield 80%) of 2,2'-azobis[N-(2-hydroxyethylamino)ethyl-2-methylpropionamide] of yellow viscous liquid.

後処理

  1. additionwas added dropwise
  2. waitAfter standing overnight
  3. extractionextracted with 100 ml of dichloromethane
  4. dry with materialThe organic layer was dried over anhydrous magnesium sulfate and solvent
  5. distillationwas distilled off

出典と根拠

ORDレコード
ord-05d71fab04fc49be9451b1ee4d2d5401
出典データセット
uspto-grants-1998_12
特許番号
US05854406

反応ノート

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