Veratraldehyde → 2-(3,4-Dimethoxy-alpha-hydroxybenzyl)benzaldehyde dimethylacetal

反応式

[CH3:1][O:2][CH:3]([O:11][CH3:12])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1Br.[CH3:13][O:14][C:15]1[CH:16]=[C:17]([CH:20]=[CH:21][C:22]=1[O:23][CH3:24])[CH:18]=[O:19]>>[CH3:1][O:2][CH:3]([O:11][CH3:12])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH:18]([OH:19])[C:17]1[CH:20]=[CH:21][C:22]([O:23][CH3:24])=[C:15]([O:14][CH3:13])[CH:16]=1

参加物

反応物 2

HCID 8419Veratraldehyde

HCID 111489431-Bromo-2-(dimethoxymethyl)benzene

生成物 1

HCID 105435802-(3,4-Dimethoxy-alpha-hydroxybenzyl)benzaldehyde dimethylacetal収率 89%

実験手順

2-bromobenzaldehyde dimethylacetal and 3,4-dimethoxybenzaldehyde are reacted in the same manner as described in Example 1-(1), whereby 2-(3,4-dimethoxy-α-hydroxybenzyl)benzaldehyde dimethylacetal is obtained as pale yellow syrup.

出典と根拠

ORDレコード: ord-207c359cdc1043819b46424a88efd4d5
出典データセット: uspto-grants-1991_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05070103

反応ノート

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