Sodium Hydroxide → 4-[2-(3,4-Dichloro-phenoxy)-acetylamino]-thiophene-3-carboxylic acid

HRID 14603ノート

反応式

HRID 14603 の反応式
C[O:2][C:3]([C:5]1[C:9]([NH:10][C:11](=[O:22])[CH2:12][O:13][C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[C:16]([Cl:21])[CH:15]=2)=[CH:8][S:7][CH:6]=1)=[O:4].[OH-].[Na+]>C(O)C>[Cl:21][C:16]1[CH:15]=[C:14]([CH:19]=[CH:18][C:17]=1[Cl:20])[O:13][CH2:12][C:11]([NH:10][C:9]1[C:5]([C:3]([OH:4])=[O:2])=[CH:6][S:7][CH:8]=1)=[O:22]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 686874584-[2-(3,4-Dichloro-phenoxy)-acetylamino]-thiophene-3-carboxylic acid methyl ester

生成物 1

HCID 160681574-[2-(3,4-Dichloro-phenoxy)-acetylamino]-thiophene-3-carboxylic acid収率 80.8%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To 4-[2-(3,4-dichloro-phenoxy)-acetylamino]-thiophene-3-carboxylic acid methyl ester (80 mg, 0.222 mmol) in suspension in ethanol was added an aqueous solution of sodium hydroxide (1N, 0.333 mL, 0.333 mmol) and the reaction mixture was stirred at room temperature for 48 hours. After such time the reaction mixture was filtered and the filtrate was neutralized by addition of an aqueous solution of hydrochloric acid (1N, 0.335 mL). The precipitate was then isolated by filtration, washed with water and dried in vacuo to yield the title compound as a white solid (62.1 mg, 80%).

後処理

  1. filtrationAfter such time the reaction mixture was filtered
  2. additionthe filtrate was neutralized by addition of an aqueous solution of hydrochloric acid (1N, 0.335 mL)
  3. customThe precipitate was then isolated by filtration
  4. washwashed with water
  5. customdried in vacuo

出典と根拠

ORDレコード
ord-1a0f7243e5134db39c034da113be3b4c
出典データセット
uspto-grants-2010_06
特許番号
US07732452B2

反応ノート

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