Allyl bromide → 3-Chloro-2-nitrophenyl allyl ether

HRID 1460369ノート

反応式

HRID 1460369 の反応式
[Cl:1][C:2]1[C:3]([N+:9]([O-:11])=[O:10])=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:18](Br)[CH:19]=[CH2:20]>CC(C)=O>[CH2:20]([O:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[C:3]=1[N+:9]([O-:11])=[O:10])[CH:19]=[CH2:18]

参加物

5

反応物 3

HCID 7841Allyl bromideHCID 11430Potassium CarbonateHCID 136221703-Chloro-2-nitrophenol

生成物 1

HCID 199816133-Chloro-2-nitrophenyl allyl ether収率 84.5%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

4.7g of 3-chloro-2-nitrophenol in 30ml of acetone were treated with 3.7g potassium carbonate and then reacted with 3.25g allylbromide under reflux for 8 hours. The reaction mixture was cooled and filtered and the residue extracted into chloroform, washed once with water, dried using sodium sulphate and 6.5g of an oily residue obtained The crude product was then purified by flash chromatography to give 4.85g of 3-chloro-2-nitrophenyl allyl ether as a colourless oil (yield 84%).

後処理

  1. temperatureunder reflux for 8 hours
  2. temperatureThe reaction mixture was cooled
  3. filtrationfiltered
  4. extractionthe residue extracted into chloroform
  5. washwashed once with water
  6. customdried
  7. customobtained The crude product
  8. customwas then purified by flash chromatography

出典と根拠

ORDレコード
ord-c88e7492dff74f3b91785b183962a305
出典データセット
uspto-grants-1991_12
特許番号
US05071468

反応ノート

読み込み中…