HCID 136341208、化合物 → 2-Amino-4-fluoro-6-methylphenol
反応式
[F:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]([OH:9])[C:4](C2C=CC=CC=2)([N:10]=NC2C=CC=CC=2O)[CH:3]=1>C(OCC)(=O)C.[Pd]>[NH2:10][C:4]1[CH:3]=[C:2]([F:1])[CH:7]=[C:6]([CH3:8])[C:5]=1[OH:9]参加物
4
実験手順
A mixture of 5.75 g (25 mmoles) of 4-fluoro-6-methyl-2-phenylazophenol (B1) and 1.1 g of 5% Pd/c in ethyl acetate was shaken in a Parr shaker under hydrogen at room temperature for 17.5 hours. The reaction mixture was filtered through celite and the filtrate concentrated to an oil which was purified on silica gel eluting with hexane-ethyl acetate, giving 3.2 g of a white solid: m.p. 97° C. (dec).
後処理
- filtrationThe reaction mixture was filtered through celite
- concentrationthe filtrate concentrated to an oil which
- customwas purified on silica gel eluting with hexane-ethyl acetate
出典と根拠
- ORDレコード
- ord-7705d81af164466f81711407ae904e9e
- 出典データセット
- uspto-grants-1991_12
- 特許番号
- US05071863
反応ノート
読み込み中…