Hydroquinone → 2,2,3,4,4,4-Hexafluorobutyl alpha-fluoroacrylate

HRID 1460849

反応式

HRID 1460849 の反応式
[F:1][C:2]([F:17])([CH:11]([F:16])[C:12]([F:15])([F:14])[F:13])[CH2:3][O:4][C:5](=[O:10])[CH:6]([F:9])[CH2:7]F.C1(C=CC(O)=CC=1)O.N12CCCC1=NCCC2>C(OCC)C>[F:9][C:6](=[CH2:7])[C:5]([O:4][CH2:3][C:2]([F:1])([F:17])[CH:11]([F:16])[C:12]([F:15])([F:14])[F:13])=[O:10]

参加物

5

反応物 3

HCID 785HydroquinoneHCID 763491,5-Diazabicyclo(4.3.0)non-5-eneHCID 147165092,2,3,4,4,4-Hexafluorobutyl 2,3-difluoropropanoate

生成物 1

HCID 147165102,2,3,4,4,4-Hexafluorobutyl alpha-fluoroacrylate収率 45.3%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

To a solution of 55.5 g (0.2 mole) of 2,3-difluoropropionic acid-2,2,3,4,4,4-hexafluorobutylester and a spatula tipful of hydroquinone in 550 ml of dry diethyl ether there was added dropwise at -10° C. a solution of 23 g (0.19 mole) of 1,5-diazabicyclo[4.3.0]non-5-ene in 140 ml of dry diethyl ether. The solvent was then distilled off in vacuo in the cold and the residue remaining was fractionated. In this way, 23 g of 2,2,3,4,4,4-hexafluorobutyl α-fluoroacrylate were obtained having a boiling point of 53° to 54° C. at 20 mbar and a purity of 98%.

後処理

  1. distillationThe solvent was then distilled off in vacuo in the cold and the residue

出典と根拠

ORDレコード
ord-1194d1dbf57d4c91bbcd0158708e0955
出典データセット
uspto-grants-1991_12
特許番号
US05072030

関連ノート

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