Methylamine → 2-(2-Propoxy-5-methylsulphamoylphenyl)purin-6-one

反応式

[CH2:1]([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]1[N:19]=[C:18]2[C:14](=[N:15][CH:16]=[N:17]2)[C:13](=[O:20])[N:12]=1)[CH2:2][CH3:3].Cl[S:22]([OH:25])(=O)=[O:23].[CH3:26][NH2:27]>>[CH2:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([S:22](=[O:25])(=[O:23])[NH:27][CH3:26])=[CH:7][C:6]=1[C:11]1[N:19]=[C:18]2[C:14](=[N:15][CH:16]=[N:17]2)[C:13](=[O:20])[N:12]=1)[CH2:2][CH3:3]

参加物

反応物 3

HCID 6329Methylamine

HCID 24638Chlorosulfonic acid

HCID 18409955HCID 18409955、化合物

生成物 1

HCID 212507872-(2-Propoxy-5-methylsulphamoylphenyl)purin-6-one

実験手順

In a similar manner to Example 18 reaction of 2-(2-propoxyphenyl)purin-6-one (0.81 g) with chlorosulphonic acid (4.5 ml), followed by reaction with methylamine in industrial methylated spirit (33%, 50 ml) yielded the title compound, 0.49 g, m.p. 245°-246° C. (recrystallised twice from aqueous ethanol).

出典と根拠

ORDレコード: ord-cca61e239f924dcc867d2c9c4b52eb43
出典データセット: uspto-grants-1991_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05073559

反応ノート

読み込み中…