4-Hydroxybenzoic Acid → 2-(Diethylamino)-2-oxoethyl 4-hydroxybenzoate

HRID 1461123ノート

反応式

HRID 1461123 の反応式
[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=1.Cl[CH2:12][C:13]([N:15]([CH2:18][CH3:19])[CH2:16][CH3:17])=[O:14].[I-].[Na+].O>CN(C)C=O>[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O:8][CH2:12][C:13]([N:15]([CH2:18][CH3:19])[CH2:16][CH3:17])=[O:14])=[O:7])=[CH:4][CH:3]=1

参加物

6

反応物 4

HCID 1354-Hydroxybenzoic AcidHCID 962WaterHCID 5238Sodium IodideHCID 16844Chloro-N,N-diethylacetamide

生成物 1

HCID 22991022-(Diethylamino)-2-oxoethyl 4-hydroxybenzoate

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 4-hydroxybenzoic acid (1.38 g, 0.01 mol), 2-chloro-N,N-diethylacetamide (1.4 g, 0.01 mol) triethylamine (1.44 ml. 0.01 mol) and sodium iodide (150 mg, 0.001 mol) in N,N-dimethylformamide (6 ml) was stirred at room temperature for 18 h. Water (100 ml) was added and the mixture allowed to stand at 4° C. for 5 h. The title compound was isolated by filtration, washed with water and recrystallized from ethanol-water to give 1.8 g. Mp 148°-149° C.

後処理

  1. waitto stand at 4° C. for 5 h

出典と根拠

ORDレコード
ord-f449d4f238b245c0972e6319c30b42ae
出典データセット
uspto-grants-1991_12
特許番号
US05073641

反応ノート

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