Thiazolidine → O,S-Dimethyl (3-Thiazolidinylcarbonyl)phosphoramidothioate

HRID 1461229ノート

反応式

HRID 1461229 の反応式
[S:1]1[CH2:5][CH2:4][NH:3][CH2:2]1.[P:6](=[O:14])([N:11]=[C:12]=[O:13])([S:9][CH3:10])[O:7][CH3:8]>CCOCC>[S:1]1[CH2:5][CH2:4][N:3]([C:12]([NH:11][P:6](=[O:14])([S:9][CH3:10])[O:7][CH3:8])=[O:13])[CH2:2]1

参加物

4

反応物 2

HCID 10444ThiazolidineHCID 14879948O,S-dimethyl phosphoroisocyanatidothioate

生成物 1

HCID 57269176O,S-Dimethyl (3-Thiazolidinylcarbonyl)phosphoramidothioate

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

A solution of 4.45 g of thiazolidine in 100 ml of ether was cooled to about 0° C. and 8.35 g of O,S-dimethyl phosphoroisocyanatidothioate was added dropwise with stirring. The mixture was allowed to warm to ambient temperature and react for about 1 hour at which time the precipitate that formed was collected by filtration. This precipitate was then recrystallized from a small amount of 2-propanol to obtain 3.6 g (28 percent of theory) of the title compound as white crystals melting at 84°-86° C.

後処理

  1. customreact for about 1 hour at which time the precipitate
  2. customthat formed
  3. filtrationwas collected by filtration
  4. customThis precipitate was then recrystallized from a small amount of 2-propanol

出典と根拠

ORDレコード
ord-e8194d1cd3714fa089ab9a12a5fef8d0
出典データセット
uspto-grants-1991_12
特許番号
US05075293

反応ノート

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