Nitric Acid → 4-Nitro-5,6,7,8-tetrahydroquinoline 1-oxide
反応式
S(=O)(=O)(O)O.[N+:6]([O-:9])(O)=[O:7].[N+:10]1([O-:20])[C:19]2[CH2:18][CH2:17][CH2:16][CH2:15][C:14]=2[CH:13]=[CH:12][CH:11]=1>O>[N+:6]([C:13]1[C:14]2[CH2:15][CH2:16][CH2:17][CH2:18][C:19]=2[N+:10]([O-:20])=[CH:11][CH:12]=1)([O-:9])=[O:7]参加物
5
実験手順
A stirred mixture of sulphuric acid (200 ml) and nitric acid (200 ml) was treated with 5,6,7,8-tetrahydroquinoline N-oxide (47 g, 315 mmol), heated at 60°-80 ° for 3h, cooled to room temperature, poured onto ice (1 Kg), diluted with water (1 1), and extracted with dichloromethane (3×500 ml). The extracts were dried (MgSO4) and evaporated in vacuo to give the product (48 g) as an oil.
後処理
- additionpoured onto ice (1 Kg)
- extractionextracted with dichloromethane (3×500 ml)
- dry with materialThe extracts were dried (MgSO4)
- customevaporated in vacuo
出典と根拠
- ORDレコード
- ord-29b71222762b4378b5653430cb999698
- 出典データセット
- uspto-grants-1991_12
- 特許番号
- US05075303
反応ノート
読み込み中…