Ammonium Carbonate → 4-Chloro-5-nitro-1,3-thiazol-2-ylamine
反応式
C(=O)([O-])[O-].[NH4+:5].[NH4+].Cl[C:8]1[S:9][C:10]([N+:14]([O-:16])=[O:15])=[C:11]([Cl:13])[N:12]=1>C(#N)C>[NH2:5][C:8]1[S:9][C:10]([N+:14]([O-:16])=[O:15])=[C:11]([Cl:13])[N:12]=1参加物
4
実験手順
10.1 g (0.105 mol) of ammonium carbonate are added to a solution of 19.9 g (0.1 mol) of 2,4-dichloro-5-nitrothiazole in 200 ml of acetonitrile, while stirring, and stirring is continued at room temperature for two days. The mixture is then stirred into 1 l of ice-water and the precipitate is filtered off, washed with water and dried. To remove unreacted 2,4-dichloro-5-nitrothiazole, the product is stirred into about 100 ml of petroleum ether at room temperature, filtered off, washed with petroleum ether and dried. 12.2 g (68.0% of theory) of 2-amino-4-chloro-5-nitrothiazole of melting point 180° C. (decomposition) are obtained.
後処理
- stirringstirring
- filtrationthe precipitate is filtered off
- washwashed with water
- customdried
- customTo remove unreacted 2,4-dichloro-5-nitrothiazole
- stirringthe product is stirred into about 100 ml of petroleum ether at room temperature
- filtrationfiltered off
- washwashed with petroleum ether
- customdried
出典と根拠
- ORDレコード
- ord-cdff517840a849afb1f0d2186b0b53d4
- 出典データセット
- uspto-grants-1991_12
- 特許番号
- US05075326
反応ノート
読み込み中…