Hydrochloric Acid → 2-(3,5-Dichlorophenyl)propan-2-amine

HRID 1461651ノート

反応式

HRID 1461651 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:11]=[C:12]([Cl:14])[CH:13]=1)[C:5]([NH:8]C=O)([CH3:7])[CH3:6].Cl.[OH-].[Na+]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:11]=[C:12]([Cl:14])[CH:13]=1)[C:5]([NH2:8])([CH3:6])[CH3:7]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 15754135N-(3,5-dichloroalpha,alpha-dimethylbenzyl)formamide

生成物 1

HCID 111950522-(3,5-Dichlorophenyl)propan-2-amine収率 98%

実験手順

A mixture of 1.16 g (5 mmol) of N-(3,5-dichloroα,α-dimethylbenzyl)formamide and 8 ml of 2N hydrochloric acid was refluxed for 30 minutes. After cooling, the reaction solution was alkalified with a sodium hydroxide aqueous solution and extracted with diethyl ether. The ether solution was washed with water, dried and then concentrated to obtain 1.0 g (yield: 98.0%) of the desired compound.

後処理

  1. temperaturewas refluxed for 30 minutes
  2. temperatureAfter cooling
  3. extractionextracted with diethyl ether
  4. washThe ether solution was washed with water
  5. customdried
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-e47868ddba874da7bb8fc5056ec5a666
出典データセット
uspto-grants-1991_12
特許番号
US05076834

反応ノート

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