Sodium Hydroxide → [3-[2-(4,5-Diphenyl-2-thiazolyl)ethyl)phenoxy]acetic acid

HRID 1461756ノート

反応式

HRID 1461756 の反応式
[C:1]1([C:7]2[N:8]=[C:9]([CH2:18][CH2:19][C:20]3[CH:21]=[C:22]([CH:29]=[CH:30][CH:31]=3)[O:23][CH2:24][C:25]([O:27]C)=[O:26])[S:10][C:11]=2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+]>CO>[C:1]1([C:7]2[N:8]=[C:9]([CH2:18][CH2:19][C:20]3[CH:21]=[C:22]([CH:29]=[CH:30][CH:31]=3)[O:23][CH2:24][C:25]([OH:27])=[O:26])[S:10][C:11]=2[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 10477744Methyl [3-[2-(4,5-diphenyl-2-thiazolyl)ethyl]phenoxy]acetate

生成物 1

HCID 15006905[3-[2-(4,5-Diphenyl-2-thiazolyl)ethyl)phenoxy]acetic acid収率 79%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of methyl [3-[2-(4,5-diphenyl-2-thiazolyl)ethyl]phenoxy]acetate (2.70 g, 6mmol), 5N NaOH solution (3.77mL, 18mmol) and methanol (40 mL) was heated to reflux on a steam bath. After 20 minutes, the mixture was cooled, the methanol removed and the residue diluted with water and 2N HCl solution. The precipitate was filtered off, washed with water and dried in air. Recrystallization from a mixture of CH2Cl2 and hexanes provide [3-[2-(4,5-diphenyl-2-thiazolyl)ethyl)phenoxy]acetic acid (1.97 g, 75%), mp 118°-120° C.

後処理

  1. temperaturewas heated
  2. temperatureto reflux on a steam bath
  3. temperaturethe mixture was cooled
  4. customthe methanol removed
  5. additionthe residue diluted with water and 2N HCl solution
  6. filtrationThe precipitate was filtered off
  7. washwashed with water
  8. customdried in air
  9. customRecrystallization
  10. additionfrom a mixture of CH2Cl2 and hexanes

出典と根拠

ORDレコード
ord-b2f6f0cd736649ea822c3377408cd6ad
出典データセット
uspto-grants-1991_12
特許番号
US05077305

反応ノート

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