Ethanethiol → HCID 13336875、化合物

反応式

[C:1]([C:3]1[C:8]([C:9]#[N:10])=[N:7][C:6](Cl)=[C:5]([CH3:12])[N:4]=1)#[N:2].[CH2:13]([SH:15])[CH3:14].[OH-].[Na+]>>[C:1]([C:3]1[C:8]([C:9]#[N:10])=[N:7][C:6]([S:15][CH2:13][CH3:14])=[C:5]([CH3:12])[N:4]=1)#[N:2]

参加物

反応物 3

HCID 6343Ethanethiol

HCID 14798Sodium Hydroxide

HCID 129071985-Chloro-6-methylpyrazine-2,3-dicarbonitrile

生成物 1

HCID 13336875HCID 13336875、化合物収率 45%

実験手順

2,3-Dicyano-5-chloro-6-methylpyrazine (1.79 g; 0.01 mole), 0.62 g (0.01 mole) of ethanethiol and 0.40 g (0.01 mole) of sodium hydroxide were worked up in the same way as in Example 8. Recrystallization from ethanol afforded 0.91 g (yield 45%) of 2,3-dicyano-5-ethylthio-6-methylpyrazine.

後処理

customRecrystallization from ethanol

出典と根拠

ORDレコード: ord-8e34c42eb7994a84976a28b6aeb1d464
出典データセット: uspto-grants-1984_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04460403

反応ノート

読み込み中…