Pyridine → 2,3-Dicyano-5-chloro-6-ethylthiopyrazine

HRID 1462305ノート

反応式

HRID 1462305 の反応式
[C:1]([C:3]1[C:8]([C:9]#[N:10])=[N:7][C:6](Cl)=[C:5]([Cl:12])[N:4]=1)#[N:2].[CH2:13]([SH:15])[CH3:14].N1C=CC=CC=1>CC(C)=O.O>[C:9]([C:8]1[C:3]([C:1]#[N:2])=[N:4][C:5]([Cl:12])=[C:6]([S:15][CH2:13][CH3:14])[N:7]=1)#[N:10]

参加物

6

反応物 3

HCID 1049PyridineHCID 6343EthanethiolHCID 6078205,6-Dichloro-2,3-dicyanopyrazine

生成物 1

HCID 128737542,3-Dicyano-5-chloro-6-ethylthiopyrazine収率 29.4%

試薬・触媒・溶媒 2

HCID 180Acetone溶媒HCID 962Water溶媒

実験手順

2,3-Dicyano-5,6-dichloropyrazine (1.00 g; 0.005 mole) and 0.47 g of ethanethiol were dissolved in 50 ml of acetone. The solution was cooled to -15° to -10° C., and a solution of 0.40 g (0.005 mole) of pyridine in 40 ml of water was added dropwise over the period of 30 minutes. The mixture was worked up in the same way as in Example 26 to afford 0.33 g (yield 29%) of 2,3-dicyano-5-chloro-6-ethylthiopyrazine.

後処理

  1. temperatureThe solution was cooled to -15° to -10° C.

出典と根拠

ORDレコード
ord-e45b35f256e542e4923d2ef801e67df9
出典データセット
uspto-grants-1984_07
特許番号
US04460403

反応ノート

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