1,1'-Carbonyldiimidazole → 11H-imidazo[1,2-c][1,3]benzodiazepin-5(6H)-one

HRID 1462330ノート

反応式

HRID 1462330 の反応式
[C:1]([N:8]1[CH:12]=[CH:11][N:10]=[CH:9]1)([N:3]1[CH:7]=[CH:6]N=C1)=[O:2].N[C:14]1[CH:25]=[CH:24]C=C[C:15]=1[CH2:16]C1NC=CN=1>C(Cl)Cl>[N:10]1[CH:11]=[CH:12][N:8]2[C:9]=1[CH2:24][C:25]1[CH:14]=[CH:15][CH:16]=[CH:6][C:7]=1[NH:3][C:1]2=[O:2]

参加物

4

反応物 2

HCID 682631,1'-CarbonyldiimidazoleHCID 133449032-[(1H-Imidazol-2-yl)methyl]aniline

生成物 1

HCID 1334492211H-imidazo[1,2-c][1,3]benzodiazepin-5(6H)-one

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Alternately, 0.75 g of 1,1'-carbonyldiimidazole was added at once to a suspension of 0.79 g of 2-(2-aminobenzyl)imidazole in 38 ml of methylene chloride and the mixture was stirred at room temperature overnight. The resulting precipitate was collected and recrystallized from methylene chloride to give the crude 11H-imidazo[1,2-c][1,3]benzodiazepin-5(6H)-one, m.p. 238°-40°.

後処理

  1. customThe resulting precipitate was collected
  2. customrecrystallized from methylene chloride

出典と根拠

ORDレコード
ord-3125d9fe71e5469eb9cf3203043bf9ca
出典データセット
uspto-grants-1984_07
特許番号
US04460508

反応ノート

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