Sodium Hydroxide → Octimibate

HRID 1462454ノート

反応式

HRID 1462454 の反応式
C[O:2][C:3](=[O:35])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][O:11][C:12]1[N:13]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[C:14]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[C:15]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[N:16]=1.[OH-].[Na+]>CO.O>[C:29]1([N:13]2[C:14]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[C:15]([C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)[N:16]=[C:12]2[O:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][C:3]([OH:35])=[O:2])[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 13279625Methyl 8-[(1,4,5-triphenyl-1H-imidazol-2-yl)oxy]octanoate

生成物 1

HCID 65676Octimibate

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

171 g of methyl-8-(1,4,5-triphenylimidazol-2-yloxy)-caprylate and 44 g of sodium hydroxide are dissolved in 1,000 ml of methanol and the mixture is stirred at room temperature for about 24 hours. The solvent is then stripped off in vacuo and the residue is taken up in water. The aqueous solution is washed with ether and acidified with dilute hydrochloric acid and the acid precipitated is separated off and dried.

後処理

  1. washThe aqueous solution is washed with ether
  2. customthe acid precipitated
  3. customis separated off
  4. customdried

出典と根拠

ORDレコード
ord-cbae23275b5641c1919af98ca6bb983a
出典データセット
uspto-grants-1984_07
特許番号
US04460598

反応ノート

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