1-(1H-Imidazol-1-yl)ethanone → 1-Acetyl-3-[4-(ethoxycarbonylmethoxy)benzyl]imidazolium bromide
反応式
[C:1]([N:4]1[CH:8]=[CH:7][N:6]=[CH:5]1)(=[O:3])[CH3:2].[Br:9][CH2:10][C:11]1[CH:23]=[CH:22][C:14]([O:15][CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:13][CH:12]=1>C(#N)C>[Br-:9].[C:1]([N+:4]1[CH:8]=[CH:7][N:6]([CH2:10][C:11]2[CH:12]=[CH:13][C:14]([O:15][CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:22][CH:23]=2)[CH:5]=1)(=[O:3])[CH3:2]参加物
4
反応条件
- 温度
- 60 °C
実験手順
2.2 g of 1-acetylimidazole and 5.46 g of ethyl 4-bromomethylphenoxyacetate were added to 5 ml of dry acetonitrile, and the mixture was heated at 60° C. for 2 hours. After completion of the reaction, the solvent was evaporated under reduced pressure. The residue was triturated with an adequate amount of dry diethyl ether and the resulting powder was collected by filtration and dried to obtain 7.5 g of 1-acetyl-3-[4-(ethoxycarbonylmethoxy)benzyl]imidazolium bromide. (98.6% yield). Colorless hygroscopic amorphous.