Hydrochloric Acid → HCID 70456409、化合物

反応式

[OH-].[Na+].[NH:3]1[CH:7]=[CH:6][N:5]=[C:4]1[CH2:8][C:9]1[CH:21]=[CH:20][C:12]([O:13][CH2:14][C:15]([O:17]CC)=[O:16])=[CH:11][CH:10]=1.[ClH:22]>O>[OH2:13].[ClH:22].[NH:3]1[CH:7]=[CH:6][N:5]=[C:4]1[CH2:8][C:9]1[CH:10]=[CH:11][C:12]([O:13][CH2:14][C:15]([OH:17])=[O:16])=[CH:20][CH:21]=1

参加物

実験手順

To a solution of 0.42 g of sodium hydroxide in 30 ml of water was added 2.3 g of ethyl 4-(1-imidazolylmethyl)phenoxyacetate and the mixture was stirred at room temperature for 20 minutes. After completion of the reaction, an adequate amount of diluted hydrochloric acid was added to the solution to make it acidic. The reaction mixture was concentrated to dryness under reduced pressure, and the residue was recrystallized from water to obtain 2.4 g of 4-(1-imidazolylmethyl)phenoxyacetic acid hydrochloride monohydrate (94.9% yield). Colorless needles.