Sodium → HCID 178444384、化合物

HRID 1463014

反応式

HRID 1463014 の反応式
CO[CH:3]=[C:4]([C@H:7]1[CH2:12][CH2:11][C@H:10]([CH2:13][CH2:14][CH3:15])[CH2:9][CH2:8]1)[CH:5]=O.Cl.[CH2:17]([C@H:22]1[CH2:27][CH2:26][C@H:25]([C:28]([NH2:30])=[NH:29])[CH2:24][CH2:23]1)[CH2:18][CH2:19][CH2:20][CH3:21].C[O-].[Na+].[Na]>CO>[CH2:13]([C@H:10]1[CH2:11][CH2:12][C@H:7]([C:4]2[CH:5]=[N:29][C:28]([C@H:25]3[CH2:26][CH2:27][C@H:22]([CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[CH2:23][CH2:24]3)=[N:30][CH:3]=2)[CH2:8][CH2:9]1)[CH2:14][CH3:15]

参加物

6

反応物 4

HCID 5360545SodiumHCID 10942334Sodium MethoxideHCID 178444523HCID 178444523、化合物HCID 178447995HCID 178447995、化合物

生成物 1

HCID 178444384HCID 178444384、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

In an analogous manner to that described in Example 3, a mixture of 3.2 g of 3-methoxy-2-(trans-4-propylcyclohexyl)acrolein, 4.1 g of trans-4-pentylcyclohexanecarboxamidine hydrochloride and 50 ml of absolute methanol is treated with a sodium methylate solution prepared from 0.53 g of sodium in 20 ml of absolute methanol. The reaction duration, working-up and chromatography are as described in Example 3. The pure fractions (in accordance with thin-layer chromatography) resulting in the chromatography are combined and recrystallized twice from hexane. There is obtained pure 5-(trans-4-propylcyclohexyl)-2-(trans-4-pentylcyclohexyl)pyrimidine; m.p. 98° C., cl.p. 178° C. (smectic).

後処理

  1. customThe pure fractions (in accordance with thin-layer chromatography) resulting in the chromatography
  2. customrecrystallized twice from hexane

出典と根拠

ORDレコード
ord-b14e87bb6ce54fea90e6b2383972742d
出典データセット
uspto-grants-1984_07
特許番号
US04462923

関連ノート

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