反応式
[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]1[C:19]2[C:14](=[CH:15][C:16]([O:22][CH3:23])=[CH:17][C:18]=2[O:20][CH3:21])[C:13]([C:24]([OH:26])=O)=[CH:12][N:11]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:27][O:28][CH2:29][CH2:30][NH2:31]>>[C:1]([O:5][C:6](=[O:7])[NH:8][CH2:9][C:10]1[C:19]2[C:14](=[CH:15][C:16]([O:22][CH3:23])=[CH:17][C:18]=2[O:20][CH3:21])[C:13]([C:24](=[O:26])[NH:31][CH2:30][CH2:29][O:28][CH3:27])=[CH:12][N:11]=1)([CH3:3])([CH3:4])[CH3:2]参加物
3
実験手順
As described in example 1E, 100 mg of 1-(tert-butoxycarbonylamino-methyl)-6,8-dimethoxy-isoquinoline-4-carboxylic acid was coupled with 2-methoxy-ethylamine to give 92 mg of [6,8-dimethoxy-4-(2-methoxy-ethylcarbamoyl)-isoquinolin-1-ylmethyl]carbamic acid tert-butyl ester. H1-NMR (CDCl3): δ, 8.46 (s, 1H), 7.34 (s, 1H), 6.73 (br s, 1H), 6.59 (s, 1H), 6.51 (br s, 1H), 5.03 (d, J=3.9 Hz, 2H), 3.98 (s, 3H), 3.95 (s, 3H), 3.75 (q, J=5.1 Hz, 2H), 3.65 (t, J=5.1 Hz, 2H), 3.43 (s, 3H), 1.54 (s, 9H).
出典と根拠
- ORDレコード
- ord-c839193ea6dc418d8f9f3cce27f99821
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07732446B1
関連ノート
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