HCID 22851231、化合物 → HCID 22851233、化合物

HRID 1463784ノート

反応式

HRID 1463784 の反応式
C([O:8][CH2:9][C@@H:10]([O:12][CH2:13][P:14]([O:20][CH:21]([CH3:23])[CH3:22])([O:16][CH:17]([CH3:19])[CH3:18])=[O:15])[CH3:11])C1C=CC=CC=1>[OH-].[OH-].[Pd+2].C(O)C.C1CCCCC=1>[CH:21]([O:20][P:14]([CH2:13][O:12][C@@H:10]([CH3:11])[CH2:9][OH:8])([O:16][CH:17]([CH3:18])[CH3:19])=[O:15])([CH3:22])[CH3:23]

参加物

4

反応物 1

HCID 22851231HCID 22851231、化合物

生成物 1

HCID 22851233HCID 22851233、化合物収率 104.1%

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 18676862Cyclohexene ethanol溶媒

実験手順

A solution of (S)-1-O-benzyl-2-O-[(diisopropylphosphono)methyl]-1,2-propanediol (8.20 g, 23.8 mmol) in 1:1 ethanol/cyclohexene (80 mL) was treated with 20% palladium hydroxide on carbon (4.0 g), and the mixture was heated at reflux for 18 hours. The reaction mixture was then filtered through a 1" pad of Celite, and the filtrate was concentrated in vacuo to give 6.3 g of the title compound as a clear, colorless oil which was used in the following reaction without purification.

後処理

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 18 hours
  3. filtrationThe reaction mixture was then filtered through a 1" pad of Celite
  4. concentrationthe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-7f46e3e48c5c4caabe937a351adb4096
出典データセット
uspto-grants-1994_04
特許番号
US05302585

反応ノート

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