Hydrochloric Acid → HCID 19087479、化合物

4-Phenyl-4-(1-piperidino)cyclohexanone of Example 3 (0.95 g, 3.7 mmol) and ammonium acetate (4.3 g, 55 mmole) were dissolved in 30 ml of anhydrous methanol. Sodium cyanoborohydride (0.5 g, 8 mmole) was added to the mixture while stirring. The mixture was stirred at room temperature overnight and concentrated HCl was then added until a white precipitate was obtained. The precipitate was removed by filtration. The filtrate was concentrated under reduced pressure to give a solid residue. The residue was taken up in 100 ml of water and to the aqueous extract was added concentrated HCl to pH 2. The solution was extracted with ethyl ether to remove the unreacted starting material. The mixture was then stirred in an ice bath and sodium hydroxide was added until the solution pH reached 11. The mixture was then extracted with chloroform. The chloroform extract was washed once with water and dried over anhydrous sodium sulfate. Removal of chloroform under reduced pressure gave the desired cyclohexylamine in quantitative yield as a white solid.

1. stirringThe mixture was stirred at room temperature overnight
2. customwas obtained
3. customThe precipitate was removed by filtration
4. concentrationThe filtrate was concentrated under reduced pressure
5. customto give a solid residue
6. extractionto the aqueous extract
7. additionwas added concentrated HCl to pH 2
8. extractionThe solution was extracted with ethyl ether
9. customto remove the
10. stirringThe mixture was then stirred in an ice bath
11. additionsodium hydroxide was added until the solution pH
12. extractionThe mixture was then extracted with chloroform
13. extractionThe chloroform extract
14. washwas washed once with water
15. dry with materialdried over anhydrous sodium sulfate
16. customRemoval of chloroform under reduced pressure

ORDレコード

ord-2a5dd1bc14dc4165b547519a63f7b6a7

出典データセット

uspto-grants-1994_04

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US05304479