Hydrochloric Acid → (3S,4S)-3-[(1R)-1-(tert-butyldimethylsilyloxy)ethyl]-4-[(1R)-1-[(methylthio)thiocarbonyl}ethyl]-2-oxoazetidine

HRID 1464722

反応式

HRID 1464722 の反応式
C(N(CC)CC)C.[C:8]([S:12][CH3:13])(=[S:11])[CH2:9][CH3:10].C(O[C@H:18]1[NH:21][C:20](=[O:22])[C@@H:19]1[C@H:23]([O:25][Si:26]([C:29]([CH3:32])([CH3:31])[CH3:30])([CH3:28])[CH3:27])[CH3:24])(=O)C.Cl>C(#N)C.[Cl-].[Zn+2].[Cl-].ClCCl>[Si:26]([O:25][C@@H:23]([C@@H:19]1[C@@H:18]([C@H:9]([C:8]([S:12][CH3:13])=[S:11])[CH3:10])[NH:21][C:20]1=[O:22])[CH3:24])([C:29]([CH3:30])([CH3:31])[CH3:32])([CH3:27])[CH3:28]

参加物

8

反応物 4

HCID 313Hydrochloric AcidHCID 8471TriethylamineHCID 223580Methyl propanedithioateHCID 10935078Azetidon

生成物 1

HCID 57309161(3S,4S)-3-[(1R)-1-(tert-butyldimethylsilyloxy)ethyl]-4-[(1R)-1-[(methylthio)thiocarbonyl}ethyl]-2-oxoazetidine収率 69.5%

試薬・触媒・溶媒 3

HCID 3007855Zincchloride触媒HCID 6342Acetonitrile溶媒2 回HCID 6344Dichloromethane溶媒

反応条件

温度
0 °C

実験手順

To a suspension of anhydrous zinc chloride (45.3 g) in acetonitrile (450 ml) cooled to 0° C. was added triethylamine (101 g). After stirring for 30 minutes at 0° C., the solution was cooled to -35° C. and a mixture of methyl dithiopropionate (20.0 g) and (3R,4R)-4-acetoxy-3-[(1R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-oxoazetidine (23.9 g) in acetonitrile (90 ml) was added thereto. The reaction mixture was stirred at -20° C. for 2 hours, warmed to 0° C., and additionally stirred for 30 minutes at 0° C. The mixture was poured into a stirred mixture of dichloromethane (800 ml) and 1N hydrochloric acid (1000 ml). The organic layer was separated, washed with water, aqueous sodium bicarbonate solution and brine, and dried. The solution was concentrated under reduced pressure and the solid residue was washed with n-hexane to afford (3S,4S)-3-[(1R)-1-(tert-butyldimethylsilyloxy)ethyl]-4-[(1R)-1-{(methylthio)thiocarbonyl}ethyl]-2-oxoazetidine (20.1 g) as a yellow crystal.

後処理

  1. temperaturethe solution was cooled to -35° C.
  2. additionwas added
  3. stirringThe reaction mixture was stirred at -20° C. for 2 hours
  4. temperaturewarmed to 0° C.
  5. stirringadditionally stirred for 30 minutes at 0° C
  6. customThe organic layer was separated
  7. washwashed with water, aqueous sodium bicarbonate solution and brine
  8. customdried
  9. concentrationThe solution was concentrated under reduced pressure
  10. washthe solid residue was washed with n-hexane

出典と根拠

ORDレコード
ord-8ebceed7fa414a45907d86cc7076cf97
出典データセット
uspto-grants-1994_04
特許番号
US05306816

関連ノート

読み込み中…