3-[3-(3-Thienyl)phenyl]-1-propanol → 3-[3-(3-Thienyl)phenyl]propanal

HRID 1464763ノート

反応式

HRID 1464763 の反応式
[S:1]1[CH:5]=[CH:4][C:3]([C:6]2[CH:7]=[C:8]([CH2:12][CH2:13][CH2:14][OH:15])[CH:9]=[CH:10][CH:11]=2)=[CH:2]1.[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1>C(Cl)(Cl)Cl>[S:1]1[CH:5]=[CH:4][C:3]([C:6]2[CH:7]=[C:8]([CH2:12][CH2:13][CH:14]=[O:15])[CH:9]=[CH:10][CH:11]=2)=[CH:2]1

参加物

4

反応物 2

HCID 199170763-[3-(3-Thienyl)phenyl]-1-propanolHCID 178418287HCID 178418287、化合物

生成物 1

HCID 199171493-[3-(3-Thienyl)phenyl]propanal収率 77.4%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

150 mg of the resulting alcohol compound was dissolved in 5 ml of chloroform, and 222 mg of pyridinium chlorochromate was added. The mixture was stirred overnight at room temperature, and then the s precipitate was removed by filtration. The filtrate was Worked up in a customary manner, and the product was purified by silica gel column chromatography [hexane/ethyl acetate=5/1] to give 115 mg Of the captioned compound as a colorless oil.

後処理

  1. customthe s precipitate was removed by filtration
  2. customthe product was purified by silica gel column chromatography [hexane/ethyl acetate=5/1]

出典と根拠

ORDレコード
ord-814ca39d43374f18801468b9cb618ea7
出典データセット
uspto-grants-1994_04
特許番号
US05306728

反応ノート

読み込み中…