4-Methyl-3-nitroaniline → tert-Butyl (4-methyl-3-nitrophenyl)carbamate

HRID 1465027ノート

反応式

HRID 1465027 の反応式
[CH3:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[C:12](=O)([OH:18])[O:13][C:14]([CH3:17])([CH3:16])[CH3:15]>C1COCC1>[CH3:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:12](=[O:18])[O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10]

参加物

4

反応物 2

HCID 83904-Methyl-3-nitroanilineHCID 3015642Mono-tert-butyl carbonate

生成物 1

HCID 18954623tert-Butyl (4-methyl-3-nitrophenyl)carbamate

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

反応条件

温度
65 °C

実験手順

4-Methyl-3-nitroaniline (5.0 g, 32.86 mmol) was dissolved in anhydrous THF (25 mL). t-Butyl bicarbonate (7.5 mL, 32.86 mmol) dissolved in anhydrous THF (25 mL) was added slowly to the reaction mixture, which was stirred at 65° C. for 18 hours. After the reaction was completed the remaining organic solvent was distilled under reduced pressure, and water was added thereto. The resulting yellow solid was filtered and dried to obtain the title compound without further purification.

後処理

  1. additionwas added slowly to the reaction mixture, which
  2. distillationwas distilled under reduced pressure, and water
  3. additionwas added
  4. filtrationThe resulting yellow solid was filtered
  5. customdried

出典と根拠

ORDレコード
ord-d547698dd7ee4a56bca561fee49ee039
出典データセット
uspto-grants-2015_04
特許番号
US08999973B2

反応ノート

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