Thionyl Chloride → 4-Ethoxy-1-(4-fluorophenyl)pyrazole-3-carbonyl chloride

HRID 1465186ノート

反応式

HRID 1465186 の反応式
[CH2:1]([O:3][C:4]1[C:5]([C:16]([OH:18])=O)=[N:6][N:7]([C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)[CH:8]=1)[CH3:2].S(Cl)([Cl:21])=O>>[CH2:1]([O:3][C:4]1[C:5]([C:16]([Cl:21])=[O:18])=[N:6][N:7]([C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)[CH:8]=1)[CH3:2]

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 336766774-ethoxy-1-(4-fluorophenyl)-1H-pyrazole-3-carboxylic acid

生成物 1

HCID 867081584-Ethoxy-1-(4-fluorophenyl)pyrazole-3-carbonyl chloride

実験手順

D3 (43 mg, 0.17 mmol, 1.0 eq.) was heated in thionyl chloride (1 mL) for 4 h at 67° C. Solvent was removed in vacuo and the crude material was resolved in dry toluene and evaporated under reduced pressure again to yield D4. The crude material was used in the next step without further purification.

後処理

  1. customSolvent was removed in vacuo
  2. customevaporated under reduced pressure again

出典と根拠

ORDレコード
ord-087e8d4a4f25427b845d58d767064a5c
出典データセット
uspto-grants-2015_04
特許番号
US08999982B2

反応ノート

読み込み中…