Thionyl Chloride → 1-(4-Fluorophenyl)-4-methoxy-pyrazole-3-carbonyl chloride

HRID 1465190

反応式

HRID 1465190 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[C:11]([O:13][CH3:14])[C:10]([C:15]([OH:17])=O)=[N:9]2)=[CH:4][CH:3]=1.S(Cl)([Cl:20])=O>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[C:11]([O:13][CH3:14])[C:10]([C:15]([Cl:20])=[O:17])=[N:9]2)=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 336766731-(4-fluorophenyl)-4-methoxy-1H-pyrazole-3-carboxylic acid

生成物 1

HCID 867081591-(4-Fluorophenyl)-4-methoxy-pyrazole-3-carbonyl chloride

実験手順

E2 (100 mg, 0.42 mmol, 1.0 eq.) was heated in thionyl chloride (1 mL) for 4 h under reflux. Solvent was removed in vacuo and the crude material was resolved in dry toluene and evaporated under reduced pressure again to yield E3. The crude material was used in the next step without further purification.

後処理

  1. temperatureunder reflux
  2. customSolvent was removed in vacuo
  3. customevaporated under reduced pressure again

出典と根拠

ORDレコード
ord-2fa6be84054c46c6b1d9512238ebc798
出典データセット
uspto-grants-2015_04
特許番号
US08999982B2

関連ノート

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