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HRID 1465200作成日：2026年10月27日

1,5-Dimethyl-1H-Pyrazole-3-Carbonyl Chloride → N-[3-fluoro-4-[[6-methoxy-7-(3-morpholinopropoxy)-4-quinolyl]oxy]phenyl]-1,5-dimethyl-pyrazole-3-carboxamide

https://huagongshe.com/reaction/1465200

反応式

関与物質

役割名称HCID仕込み量
反応物1,5-Dimethyl-1H-Pyrazole-3-Carbonyl ChlorideHCID 2776364—
反応物3-Fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)anilineHCID 46928040—
生成物N-[3-fluoro-4-[[6-methoxy-7-(3-morpholinopropoxy)-4-quinolyl]oxy]phenyl]-1,5-dimethyl-pyrazole-3-carboxamideHCID 56846800—

反応手順

Q5 was prepared from 3-fluoro-4-[[6-methoxy-7-(3-morpholinopropoxy)-4-quinolyl]oxy]aniline and 1,5-dimethyl-1H-pyrazole-3-carbonyl chloride following the general procedure reported in Preparative Example 1 Step 3. MS (ES) C29H32FN5O5 requires: 549. Found: 550 (M+H)+.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08999982B2
出典データセットuspto-grants-2015_04
ORD IDord-0333246740124ccc95786828def1581a
出典メモuspto-grants-2015_04