HRID1465200

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2776364

1,5-Dimethyl-1H-Pyrazole-3-Carbonyl Chloride

C6H7ClN2O

结构：COc1cc2c(Oc3ccc(N)cc3F)ccnc2cc1OCCCN1CCOCC1

HCID46928040

未命名化合物

PRODUCTS

生成物

结构：COc1cc2c(Oc3ccc(NC(=O)c4cc(C)n(C)n4)cc3F)ccnc2cc1OCCCN1CCOCC1

HCID56846800

未命名化合物

PROCEDURE

实验过程

Q5 was prepared from 3-fluoro-4-[[6-methoxy-7-(3-morpholinopropoxy)-4-quinolyl]oxy]aniline and 1,5-dimethyl-1H-pyrazole-3-carbonyl chloride following the general procedure reported in Preparative Example 1 Step 3. MS (ES) C29H32FN5O5 requires: 549. Found: 550 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0333246740124ccc95786828def1581a
来源数据集: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08999982B2
来源说明: uspto-grants-2015_04

反应 SMILES

[F:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[O:9][C:10]1[C:19]2[C:14](=[CH:15][C:16]([O:22][CH2:23][CH2:24][CH2:25][N:26]3[CH2:31][CH2:30][O:29][CH2:28][CH2:27]3)=[C:17]([O:20][CH3:21])[CH:18]=2)[N:13]=[CH:12][CH:11]=1)[NH2:5].[CH3:32][N:33]1[C:37]([CH3:38])=[CH:36][C:35]([C:39](Cl)=[O:40])=[N:34]1>>[F:1][C:2]1[CH:3]=[C:4]([NH:5][C:39]([C:35]2[CH:36]=[C:37]([CH3:38])[N:33]([CH3:32])[N:34]=2)=[O:40])[CH:6]=[CH:7][C:8]=1[O:9][C:10]1[C:19]2[C:14](=[CH:15][C:16]([O:22][CH2:23][CH2:24][CH2:25][N:26]3[CH2:31][CH2:30][O:29][CH2:28][CH2:27]3)=[C:17]([O:20][CH3:21])[CH:18]=2)[N:13]=[CH:12][CH:11]=1