Triphenylphosphine → [4-(Benzyloxy)benzyl](triphenyl)phosphonium chloride

HRID 1465482

反応式

HRID 1465482 の反応式
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][Cl:16])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:17]1([P:23]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>C1(C)C=CC=CC=1>[Cl-:16].[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][P+:23]([C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 11776TriphenylphosphineHCID 700424-Benzyloxybenzyl chloride

生成物 1

HCID 383834[4-(Benzyloxy)benzyl](triphenyl)phosphonium chloride収率 88.1%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To a suspension of 1-(benzyloxy)-4-(chloromethyl)benzene (4.890 g, 21.01 mmol) in toluene (25 ml) was added triphenylphosphine (6.617 g, 25.23 mmol). The mixture was heated under reflux for 24 hrs, and cooled to room temperature. The precipitate was collected by filtration, and dried under reduced pressure to give [4-(benzyloxy)benzyl](triphenyl)phosphonium chloride (9.166 g, yield 88.1%) as a white solid.

後処理

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 24 hrs
  3. filtrationThe precipitate was collected by filtration
  4. customdried under reduced pressure

出典と根拠

ORDレコード
ord-813e6d3b514547329678200b2299595c
出典データセット
uspto-grants-2015_04
特許番号
US08999989B2

関連ノート

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