Bromine → HCID 86657727、化合物

HRID 1465598ノート

反応式

HRID 1465598 の反応式
[CH3:1][C:2]1[C:7]([C:8](=[O:10])[CH3:9])=[C:6]([CH3:11])[CH:5]=[C:4]([CH3:12])[N:3]=1.[Br:13]Br>Br.C(O)(=O)C>[BrH:13].[Br:13][CH2:9][C:8]([C:7]1[C:2]([CH3:1])=[N:3][C:4]([CH3:12])=[CH:5][C:6]=1[CH3:11])=[O:10]

参加物

5

反応物 2

HCID 24408BromineHCID 2681241-(2,4,6-Trimethylpyridin-3-yl)ethan-1-one

生成物 1

HCID 86657727HCID 86657727、化合物

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒2 回HCID 260Hydrogen Bromide溶媒

反応条件

温度
70 °C

実験手順

To a solution of 1-(2,4,6-trimethylpyridin-3-yl)ethanone (5.0 g, 30.6 mmol) in 33% HBr in acetic acid solution (10.2 mL) was added bromine (1.57 ml, 30.6 mmol) in acetic acid (10.2 mL) dropwisely. The reaction was stirred at 70° C. for 2.0 h. The solution was cooled to room temperature and washed with ether. The residue was dried under reduced pressure to give 2-bromo-1-(2,4,6-trimethylpyridin-3-yl)ethanone hydrobromide, which was used directly for the next step without further purification.

後処理

  1. temperatureThe solution was cooled to room temperature
  2. washwashed with ether
  3. customThe residue was dried under reduced pressure

出典と根拠

ORDレコード
ord-9d6118915bef4fbf99a9b421e3fa4b44
出典データセット
uspto-grants-2015_04
特許番号
US08999983B2

反応ノート

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