Methyl 5-methoxynicotinate → Methyl 5-methoxypiperidine-3-carboxylate
反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]([O:11][CH3:12])=[O:10])[CH:6]=[N:7][CH:8]=1>Cl.CO.[Pt](=O)=O>[CH3:1][O:2][CH:3]1[CH2:8][NH:7][CH2:6][CH:5]([C:9]([O:11][CH3:12])=[O:10])[CH2:4]1参加物
5
実験手順
Methyl 5-methoxypyridine 3-carboxylate (1 g, 6.02 mmol) and platinum (IV) oxide (50 mg) suspended in 1.25 M HCl in methyl alcohol (10 mL) were hydrogenated in Parr shaker under 40 psi overnight. The reaction mixture was filtered through a pad of celite, washed with MeOH and concentrated to give crude product.
後処理
- customwere hydrogenated in Parr shaker under 40 psi overnight
- filtrationThe reaction mixture was filtered through a pad of celite
- washwashed with MeOH
- concentrationconcentrated
- customto give crude product
出典と根拠
- ORDレコード
- ord-b08db43995ce49609d6a0676ce25b091
- 出典データセット
- uspto-grants-2015_04
- 特許番号
- US08999966B2
反応ノート
読み込み中…