Trifluoroacetic acid → HCID 89525152、化合物

反応式

[C:1]([C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[C:8]([N:13]3[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][C:14]3=[O:26])[CH:9]=[N:10]2)=[CH:5][CH:4]=1)#[N:2].C(O)(C(F)(F)F)=O>>[O:26]=[C:14]1[CH2:15][NH:16][CH2:17][CH2:18][N:13]1[C:8]1[CH:9]=[N:10][C:11]2[C:6]([CH:7]=1)=[CH:5][CH:4]=[C:3]([C:1]#[N:2])[CH:12]=2

参加物

反応物 2

HCID 6422Trifluoroacetic acid

HCID 131732664HCID 131732664、化合物

生成物 1

HCID 89525152HCID 89525152、化合物

実験手順

tert-Butyl 4-(7-cyanoquinolin-3-yl)-3-oxopiperazine-1-carboxylate (0.030 g, 0.099 mmol) was treated with TFA (2 mL) and stirred for 20 minutes. Analysis of the reaction mixture by LC indicated that reaction had gone to completion. The solution was concentrated in vacuo and crude was azetroped with dichloroethane (3×8 mL) to furnish the title product. LC/MS (IE, m/z): [M+1]+=253.

後処理

customAnalysis of the reaction mixture by LC indicated that reaction
concentrationThe solution was concentrated in vacuo and crude

出典と根拠

ORDレコード: ord-bdb65c0c4a6c45c3bfea573c18d43d16
出典データセット: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08999991B2

反応ノート

読み込み中…

参加物