3-Amino-N,N-dimethyl-4-nitroaniline → N4,N4-dimethylbenzene-1,2,4-triamine

HRID 1465802

反応式

HRID 1465802 の反応式
[CH3:1][N:2]([CH3:13])[C:3]1[CH:4]=[CH:5][C:6]([N+:10]([O-])=O)=[C:7]([CH:9]=1)[NH2:8]>[Pd].C(OCC)(=O)C.CO>[NH2:8][C:7]1[CH:9]=[C:3]([N:2]([CH3:13])[CH3:1])[CH:4]=[CH:5][C:6]=1[NH2:10]

参加物

4

反応物 1

HCID 27334513-Amino-N,N-dimethyl-4-nitroaniline

生成物 1

HCID 417238N4,N4-dimethylbenzene-1,2,4-triamine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 21584119Ethylacetate methanol溶媒

実験手順

A solution of 5-dimethylamino-2-nitroaniline (1.94 g, 10.7 mmol) in 4:1 ethyl acetate/methanol (200 ml) was treated with 5% palladium on carbon (1.12 g) and stirred under an atmosphere of hydrogen at room temperature for 20.5 h. The suspension was quickly filtered through celite, the residue washed with methanol and the combined filtrate and washings concentrated to give the crude 2-amino-4-(dimethylamino)aniline as a dark brown oil, which was used without further purification in the next step.

後処理

  1. filtrationThe suspension was quickly filtered through celite
  2. washthe residue washed with methanol
  3. concentrationthe combined filtrate and washings concentrated

出典と根拠

ORDレコード
ord-c3e59647387645ab94fce406eff33dbe
出典データセット
uspto-grants-2015_04
特許番号
US08999993B2

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