1-(2-Chloro-4-fluoro-5-nitrophenyl)-3-methyl-s-triazine-2,4,6(1H,3H,5H)-trione → 1-(5-Amino-2-chloro-4-fluorophenyl)-3-methyl-s-triazine

HRID 1466

反応式

HRID 1466 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([N+:9]([O-])=O)=[CH:4][C:3]=1[N:12]1[C:17](=O)[NH:16][C:15](=O)[N:14]([CH3:20])[C:13]1=O.[H][H]>[Pt].C(OCC)(=O)C>[NH2:9][C:5]1[C:6]([F:8])=[CH:7][C:2]([Cl:1])=[C:3]([N:12]2[CH:17]=[N:16][CH2:15][N:14]([CH3:20])[CH2:13]2)[CH:4]=1

参加物

5

反応物 2

HCID 572803321-(2-Chloro-4-fluoro-5-nitrophenyl)-3-methyl-s-triazine-2,4,6(1H,3H,5H)-trioneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 1317205461-(5-Amino-2-chloro-4-fluorophenyl)-3-methyl-s-triazine

試薬・触媒・溶媒 2

HCID 23939Platinum触媒HCID 8857Ethyl Acetate溶媒

実験手順

A mixture of 1-(2-chloro-4-fluoro-5-nitrophenyl)-3-methyl-s-triazine-2,4,6(1H,3H,5H)-trione (28.5 g, 0.09 mol) and 5% platinum on activated carbon (1 g) in ethyl acetate is hydrogenated at 55 psi until hydrogen uptake is complete. The reaction mixture is then filtered and concentrated in vacuo to give the title product as a white solid, mp 244°-245° C.

後処理

  1. filtrationThe reaction mixture is then filtered
  2. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-08b8b8866d334d3cae4bec9581c21467
出典データセット
uspto-grants-1998_03
特許番号
US05726126

関連ノート

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