Trifluoroacetic acid → HCID 26192529、化合物

HRID 1466005ノート

反応式

HRID 1466005 の反応式
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[O:11][CH2:12][C@H:13]1[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14]1.FC(F)(F)C(O)=O>>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[O:11][CH2:12][C@H:13]1[CH2:17][CH2:16][NH:15][CH2:14]1

参加物

3

反応物 2

HCID 6422Trifluoroacetic acidHCID 67349749HCID 67349749、化合物

生成物 1

HCID 26192529HCID 26192529、化合物

実験手順

The procedure is the same as for Example 2 (Stage 2.2) starting from 1.75 g (5.34 mmol) of tert-butyl (S)-3-(naphth-2-yloxymethyl)pyrrolidine-1-carboxylate and 5.00 ml (67.31 mmol) of trifluoroacetic acid. The product is obtained in the form of an oil after purification on a column of silica gel, elution being carried out with a dichloromethane/methanol/aqueous ammonia (90/9/1) mixture.

後処理

  1. customThe product is obtained in the form of an oil
  2. customafter purification
  3. washon a column of silica gel, elution

出典と根拠

ORDレコード
ord-c3fe7ac69638490b831efef253fa47ff
出典データセット
uspto-grants-2015_04
特許番号
US09000010B2

反応ノート

読み込み中…